Endocrine Abstracts

Early life events can have short and long-term effects on neuroendocrine, autonomic, and behavioural responses to stress and appear to play an important role in the etiology of stress-related disorders. Glucocorticoids are thought to be key mediators of these brain-endocrine-immune connections. We investigated the effects of a short-term social isolation (4 h) of domestic piglets at different days of age (7, 21, 35) both on behavioural alterations in open-field tests and on mo...

Imbalanced maternal nutrition during pregnancy can cause fetal growth retardation, metabolic changes and alterations of the hypothalamic–pituitary–adrenal (HPA) system in the offspring. Here, we investigated the effects of maternal low and high protein diets during pregnancy in pigs on materno-fetal HPA regulation and expression of glucocorticoid receptor (GR), mineralocorticoid receptor (MR), 11β-hydroxysteroid dehydrogenase 1 and 2 (11β-HSD1 and 11β-...